68-6

58/104

Stuart GILMOUR3), Toshiaki SHIMIZU2)1)Division of Pediatrics, Toshima Hospital, Tokyo, JapanTakuya ADACHI4), Ken HISATA2), Tomoyuki NAKAZAWA1, 2), Mahbubur RAHMAN3), 2)Department of Pediatrics, Juntendo University, Tokyo, Japan4)Division of Infectious Disease, Toshima Hospital, Tokyo, Japan3)Graduate School of Public Health, St. Luke`s International University, Tokyo, JapanHiroyuki SATO1, 2), Hiromi YAGISAWA1, 2), Karin OSHIMA1, 2), Nao MIYAZAKI1, 2), Corresponding author: Yayoi MuranoDivision of Pediatrics, Toshima Hospital33-1 Sakaecho, Itabashi-ku, Tokyo 175-0013, JapanTEL: +81-3-5375-1234　E-mail: ymurano@juntendo.ac.jp〔Received　Feb. 27, 2022〕〔Accepted　Sep. 26, 2022〕J-STAGE Advance published date: Dec. 14, 2022Copyright © 2022 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited. doi: 10.14789/jmj.JMJ22-0005-OAObjectives: COVID-19 (Coronavirus Disease 2019) is now a global pandemic. Although children are said to have mild symptom, their clinical features are not known well. We conducted a retrospective study during initial term of pandemic to understand the difference of clinical features including clinical symptoms and patients’ characteristics of COVID-19 children and those without COVID-19.Materials: To compare clinical features between children with and without COVID-19, we collected data on children who received a COVID-19 test between March 25th and October 31st, 2020. All data were collected from medical records.Methods: There were three groups of patients in the study sample; patients with COVID-19, patients with close COVID-19 contact and performed COVID-19 tests, and patients suspected COVID-19 but tested negative. We analyzed the clinical features of the groups.Results: A total of 108 patients were included in this study, of whom 30 were patients with COVID-19, 25 were patients with close COVID-19 contact, 51 were suspected COVID-19 but tested negative, and two were excluded because they were infants born from COVID-19 mothers. The statistical analysis showed that children with COVID-19 had contact with COVID-19 patients had fewer clinical symptoms including cough and fever compared to children with a negative test of COVID-19. Sensitivity analysis showed that fever, cough, fever and/or cough could not distinguish children with COVID-19 from those without COVID-19. As conclusion, children with COVID-19 have less symptoms as fever or cough and the clinical symptoms cannot distinguish them from children with other diseases.Key words: children, corona virus, COVID-19, SARS-CoV-2, pandemicJuntendo Medical Journal2022. 68(6), 622-626Original ArticlesClinical Features of Children with COVID-19 in Initial Time of PandemicIntroductionCOVID-19 (Coronavirus Disease 2019), an infec-tion caused by SARS-CoV-2 (Severe acute respi-ratory syndrome coronavirus 2), has become a global pandemic. The pandemic has occurred in waves and gradually affecting younger age groups1), whose symptoms are reported to be milder than in adults2, 3), though the reasons remain unclear4). Although their symptoms can be milder, children can be infected via family members and may also play an important role as transmission vectors5, 6), Takahiko HAYASHI1, 2), Yayoi MURANO1, 2, 3), Yamato MUTO1, 2), Michihiko TAKASU1, 2), 622