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χ2 test for multiple outcomes, Fisher’s exact test for dichotomous outcomes involving small samples, Student’s t test for continuous variables with normal distribution, or the Mann–Whitney nonpara-metric test for non-normal distributions. The level of significance was set at p<0.05. Analyses were performed using JMP software, version 14, from SAS Institute Inc. (Cary, NC).Between January 2015 and June 2020, 61 patients underwent stoma construction after colorectal surgery. Twenty-one patients received only PSC (control group), and 40 received PSC and NPWT (NPWT group). Eight patients who did not fully receive NPWT were excluded. The causes of complications were pain due to suction pressure in 4 patients, bleeding in 3, and intraabdominal abscess in 1. In total, 53 patients were included in the anal-ysis, 21 of whom had their stoma closed by PSC and 32 who had their stoma closed by PSC plus NPWT. The V.A.C® system was used for 19 patients and the PICO® system was used for 13 (Figure 1).No significant differences were observed in sex, age, body mass index, neoadjuvant chemotherapy, diabetes, corticosteroids, preoperative albumin Figure 1 The patient selection flowchartPSC: purse-string skin closure NPWT: negative-pressure wound therapylevel, type of stoma, stoma holding period, duration of surgery, operative blood loss or follow-up period between the two groups (Table 1). The RR of patients in the control group was 38.9±34.1% (4POD) and 51.5±32.7% (7POD), and that in the NPWT group was 38.3±41.1% (4POD) and 68.8± 20.0% (7POD) (Figure 2). The RR in the NPWT group was significantly smaller than that in the control group at 7POD (p=0.04), although there was no significant difference between the two groups at 4POD (p=0.48). No significant difference was observed between the two groups in the scar-ring period (p=0.11). Patients in the control group and NPWT group required 30 (17-65) and 27.5 (11-52) days for complete wound scarring, respec-tively (Figure 3).Postoperative wound-related complications were observed in 4 (19%) patients in the control group and in 7 (21.9%) patients in the NPWT group (p=1.0). Incisional SSI was confirmed in 1 patient in each group. Dermatitis was confirmed in 2 patients in the control group and in 1 patient in the NPWT group. Bleeding was confirmed in 2 patients in the NPWT group. All of these events were CD grade 2 or less. Enterocutaneous fistula was not noted in either group. Ventral hernias were 601Results

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