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p=0.503516undifferentiated vascular smooth muscle cells12). In 2010, Takahashi et al. found that serum soluble LR11(sLR11) was an indicator of coronary artery stenosis13). Furthermore, it has been noted in recent years that sLR11 has characteristics as a biomarker for malignant tumors, where its levels increased Figure 1 Distribution of serum LR11 levels in patients with esophageal cancerFigure 2 Depth of tumor invasion (T factor)* and serum LR11 levels in patients with esophageal cancerT: UICC TNM Classification of Malignant Tumors, 7th editionp=0.507Figure 3 Lymph node metastasis (N factor)* and serum LR11 levels in patients with esophageal cancer*: UICC TNM Classification of Malignant Tumors, 7th editionwith the exacerbation of acute leukemia, normal-ized with remission, and increased significantly with tumor infiltration into the bone marrow14, 15). Not only in the serum, LR-11 levels reported significantly higher in the bile from biliary tract cancer and pancreas cancer patients than in those

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