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Figure 5 Rate of change from the testing first year (write an initial value for 1)tial diagnosis. The severity and extent significantly increased in the AD and DLB groups. In other words, the significant increase in severity reflected the conversion and aggravation into AD and DLB. In contrast, the ratio was not significantly different between the groups, meaning that the ratio was almost constant regardless of the severity. These trends are consistent with previous studies using eZIS that involved healthy elderly people and mild to serious AD patients (Matsuda et al.)14-16).510Figure 6 The correlation between MMSE and CIScore in each groupThe above results suggest that severity and extent are useful indices for evaluating the conver-sion of MCI into AD and DLB. However, no signifi-cant difference was observed between the AD and DLB groups. Therefore, use of the VOI1, the volume of interest of DLB, is the most effective means of differentiating MCI from DLB.In contrast, it was suggested that CIScore is not suitable for evaluating conversion from MCI to AD and DLB. The VOI1 is the volume of interest of

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