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468Figure 1 Chlorine dioxide combats infectionsProfessor Kaoru Obinata leads a project aiming to reduce the risk of nosocomial infections through the development of reliable infection countermeasuresby screening for drug-resistant bacteria and genetically testing pathogenic microorganism • Identify effective countermeasures for each route of infectionenvironment after careful consideration and discussion by the committee and their approval.Have you had any results that you are particularly pleased with? Chlorine dioxide gas generating gel was installed in each room of the pediatric ward in a city hospital during the winter months when infectious gastroenteritis was prevalent, and we were able to conduct a study on the effect of preventing secondary infections of the infectious gastroenteritis using an aqueous solution of chlorine dioxide. As a result of examination of the four seasons since 2016, it was confirmed that there were no secondary infections of infectious gastroenteritis observed and there were no reported adverse events. Finally, what are your future plans for this research?We would like to examine our work’s impact on infection prevention against the COVID-19 virus, which is wreaking havoc around the world at present. We are also interested in seeing the effect on the mutant strains that are now appearing on a regular basis.www.impact.pub 37What issues are you trying to solve with your research?is focused on doing just this with the aim of helping many patients across Japan and beyond.Nosocomial pneumonia is a form of pneumonia that develops 48 hours after admission and the causative microorganisms include not only general bacteria but also drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDRPA). Nosocomial pneumonia has a high mortality rate and incidence rate, and is a major problem in terms of the medical expenses it incurs for patients. One of the preventive measures for nosocomial pneumonia includes environmental improvement such as disinfection and cleaning of hospital rooms. However, control of infection through the spatial environment is also important, and the establishment of economically healthy and effective infection prevention measures is desired. That is where our work comes in. By screening for drug-resistant bacteria such as MRSA and MDRPA – as well as genetically testing pathogenic microorganism using multiplex polymerase chain reactions (PCR), we can clarify the route of infection transmission and take effective countermeasures for each route of infection. Our team at the Department of Pediatrics, Juntendo University in Japan From your perspective, what is the ultimate impact of your research?In this research, in order to examine the efficacy and safety of chlorine dioxide on aerosol infection and contact infection, we will regularly conduct active surveillance for patients admitted in high care rooms or ward. There may be negative and skeptical opinions in the medical field because there is no widespread awareness of the safety and efficacy of low-concentration chlorine dioxide. So, by confirming the preventive efficacy and safety of chlorine dioxide against nosocomial pneumonia, we can expect the establishment of a new nosocomial infection control method with less human and economic burden. Ultimately, it will be beneficial not only for the inpatients but also for the hospitals. Can you talk about the challenges you have faced in your research?Since ethical support is required when using chlorine dioxide gas in a manned environment, there was a need for us to obtain approval from the ethics committee of each hospital and institution. It can only be installed and applied in an actual hospital Impact Objectives• Clarify the route of infection transmission Chlorine dioxide combats infections

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