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2)Medical Technology Innovation Center, Juntendo University, Tokyo, Japan1)Division of Medical Education, Juntendo University School of Medicine, Tokyo, Japan3)Clinical and Translational Research Center, Kobe University Hospital, Kobe, Japan(jRCT) database prepared by the Ministry of Health, Labor and Welfare4). The clinical trial implementa-tion system includes information on the principal investigator, co-investigators, program manager, study manager, data managers, monitors, biostatis-ticians, and auditors5).Key words: clinical research support, core clinical research hospital, the Japan Registry of Clinical Trials (jRCT)Corresponding author: Yuji NishizakiDivision of Medical Education, Juntendo University School of Medicine2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421, Japan.TEL: +81-3-3813-3111　FAX: +81-3-5689-0627　E-mail: ynishiza@juntendo.ac.jp〔Received　Mar. 8, 2022〕〔Accepted　Apr. 13, 2022〕J-STAGE Advance published date: Jul. 14, 2022Copyright © 2022 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited. doi: 10.14789/jmj.JMJ22-0011-PJuntendo Medical Journal2022. 68(4), 413-415PerspectivesClinical Research Support Activities in Core Clinical Research Hospitals Throughout JapanCore clinical research hospitalIn Japan, the Medical Care Act has established core clinical research hospitals that are designated to play a leading role in physician-led clinical trials. Moreover, they are responsible for the development of clinical research aimed at uncovering novel inno-vative pharmaceuticals and medical instruments in Japan according to international standards. These hospitals are also mandated to support clinical research developed in other medical institutions1-2). The Clinical Research Act, which came into effect on April 1, 2018 in Japan3), seeks to prevent research misconduct and ensure the reliability of the clinical studies for not only the research subjects but also the general public. As stipulated by the mentioned legislation, the implementation plans and research outlines of clinical trials are required to be regis-tered with the Japan Registry of Clinical Trials To the best of our knowledge, no previous research has objectively investigated supporting activities for clinical trials in core clinical research hospitals throughout Japan. Therefore, we sought to eval-uate the current status of supporting activities in core clinical research hospitals across Japan using jRCT data. Data for a total of 860 hospitals regis-tered in the jRCT from April 1, 2018 to May 31, 2019, including non-core clinical research hospitals, were reviewed, excluding unknown data. We inves-413Yuji NISHIZAKI1, 2), Rieko UEDA2), Shuko NOJIRI2), Shoji SANADA3)　We evaluated the current status of supporting activities in core clinical research hospitals across Japan using the Japan Registry of Clinical Trials (jRCT) data given the lack of previous research objectively investigated supporting activities for clinical trials in core clinical research hospitals throughout Japan. Briefly, our findings showed that despite the officially supposed cooperation scheme, core clinical research hospitals have not been the primarily selected contractor for clinical research supporters. Considering that core clinical research hospitals are designated spearhead physician-led clinical trials and are responsible for ensuring the quality of such trials, there is a need to determine why the officially supposed cooperative scheme between core and non-core hospitals are still not established in Japan in order to increase the development and quality of Japanese clinical research with maximum efficiency moving forward.Clinical research support activities in core clinical research hospitals