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Immunohistochemical analysesThe results of proteomic analysis of monkey CB included the Rab8 protein (No.170), which is a small GTP-binding protein that is related to the glaucoma gene optineurin, and is known to be involved in protein localization and transportation in the small intestine and can affect the morphology of microvilli18). The ezrin (No.70)/radixin (No.160)/moesin (No.108), ERM family, which are core proteins in the microvilli that also act as linker identified a total of 813 proteins. Detailed informa-tion on these proteins is shown as supplemental data. These proteins were classified by a biological process registered in the Gene Ontology database that uses pathway tool software (MetaCore, Gene GO, Infocom; Figure 1). The proteins identified in the CB are involved in protein transport, localiza-tion, and secretion (Table 1). The pathway tool software (MetaCore,Gene GO,Infocom) was used to classify all of the identified proteins by the biological process registered in the Gene Ontology database. Upper bar, proteins identified mainly in the ciliary epithelium; lower bar, proteins identified mainly in the ciliary stroma342Figure 1　Classification according to the Gene Ontology database1. catabolic process2. cellular catabolic process3. small molecule metabolic process4. macromolecular complex subunit organization5. cellular macromolecular complex subunit organization6. cellular component organization7. cellular component organization or biogenesis8. cellular component assembly9. cellular component biogenesis10. cellular component assembly at cellular level11. purineribonucleosidetriphosphatemetabolic process12. cellular component organization at cellular level13. purinenucleoside triphosphatemetabolic process14. ribonucleosidetriphosphatemetabolic process15. metabolic process16. cellular component organization or biogenesis at cellular level17. nucleoside triphosphatemetabolic process18. purineribonucleotidemetabolic process19. cellular metabolic process20. ribonucleotidemetabolic process21. generation of precursor metabolites and energy22. macromolecular complex assembly23. cellular macromolecular complex assembly24. nucleoside phosphate metabolic process25. nucleotide metabolic process26. purinenucleotide metabolic process27. nucleobase-containing small molecule metabolic process28. organellaorganization29. purineribonucleosidetriphosphatecatabolic process30. ribonucleosidetriphosphatecatabolic process31. oxidation-reduction process32. purinenucleoside triphosphatecatabolic process33. nucleosomeassembly34. heterocyclemetabolic process35. purineribonucleotidecatabolic process36. nucleoside triphosuphatecatabolic process37. ribonucleotidecatabolic process38. purine-containing compound metabolic process39. chromatin assembly40. purinenucleotide catabolic process41. purine-containing compound catabolic process42. protein-DNA complex assembly43. nucleosomeorganization44. nucleotide catabolic process45. nucleobase-containing compound catabolic process46. Heterocyclecatabolic process47. carbohydrate derivative catabolic process48. Cellular nitrogen compound catabolic process49. protein-DNA complex subunit organization50. Chromatin assembly or disassembly