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1) Camilleri M, Lasch K, Zhou W: Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The conflu-ence of increased permeability, inflammation, and pain in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol, 2012; 303: G775-G785. 2) Devanarayana NM, Rajindrajith S, Pathmeswaran A, Abegunasekara C, Gunawardena NK, Benninga MA: Epidemiology of irritable bowel syndrome in children and adolescents in Asia. J Pediatr Gastroenterol Nutr, 2015; 60: 792-798. 3) Devanarayana NM, Rajindrajith S: Irritable bowel syndrome in children: Current knowledge, challenges and opportunities. World J Gastroenterol, 2018; 24: 2211-2235. 4) Hyams JS, Di Lorenzo C, Saps M, Shulman RJ, Staiano A, van Tilburg MA: Childhood Functional Gastrointes-tinal Disorders: Child/Adolescent. Gastroenterology, 2016; 150: 1456-1468. 5) Bazzocchi G, Ellis J, Villanueva-Meyer J, Reddy SN, Mena I, Snape WJ: Effect of eating on colonic motility and transit in patients with functional diarrhea. Simul-taneous scintigraphic and manometric evaluations. Gastroenterology, 1991; 101: 1298-1306. 6) Miyata K, Kamato T, Nishida A, et al: Role of the sero-tonin3 receptor in stress-induced defecation. J Phar-macol Exp Ther, 1992; 261: 297-303. 7) Mönnikes H, Schmidt BG, Raybould HE, Taché Y: CRF in the paraventricular nucleus mediates gastric and colonic motor response to restraint stress. Am J Physiol, 1992; 262: G137-G143. 8) Drossman DA: The functional gastrointestinal disor-ders and the Rome III process. Gastroenterology, 2006; 130: 1377-1390. 9) Fukudo S, Nomura T, Hongo M: Impact of corticotropin- releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut, 1998; 42: 845-849.10) Atkinson W, Lockhart S, Whorwell PJ, Keevil B, Houghton LA: Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predomi-nant irritable bowel syndrome. Gastroenterology, 2006; 130: 34-43.11) Volk N, Lacy B: Anatomy and Physiology of the Small Bowel. Gastrointest Endosc Clin N Am, 2017; 27: 1-13.12) Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant, 2013; 48: 452-458.13) Murakami T, Kamada K, Mizushima K, et al: Changes in Intestinal Motility and Gut Microbiota Composition in a Rat Stress Model. Digestion, 2017; 95: 55-60.14) Bradesi S, Schwetz I, Ennes HS, et al: Repeated expo-sure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastro-intest Liver Physiol, 2005; 289: G42-G53.15) Nakade Y, Fukuda H, Iwa M, et al: Restraint stress stimulates colonic motility via central corticotropin-re-leasing factor and peripheral 5-HT3 receptors in conscious rats. Am J Physiol Gastrointest Liver Physiol, 2007; 292: G1037-G1044.16) Kellow JE, Phillips SF: Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology, 1987; 92: 1885-1893.17) Hebden JM, Blackshaw E, D’Amato M, Perkins AC, Spiller RC: Abnormalities of GI transit in bloated irri-table bowel syndrome: effect of bran on transit and symptoms. Am J Gastroenterol, 2002; 97: 2315-2320.18) Hardy JG, Wood E, Clark AG, Reynolds JR: Whole-bowel transit in patients with the irritable bowel syndrome. Eur J Nucl Med, 1986; 11: 393-396.19) Bardhan KD, Bodemar G, Geldof H, et al: A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treat-ment of irritable bowel syndrome. Aliment Pharmacol Ther, 2000; 14: 23-34.20) Chadwick VS, Chen W, Shu D, et al: Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology, 2002; 122: 1778-1783.21) Weston AP, Biddle WL, Bhatia PS, Miner PB: Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci, 1993; 38: 1590-1595.281Author contributionsT.K., M.S., T.I. and K.S. formulated the ideas, research goals and aims, and development or design of methodology; M.S., T.I., T.K. and Y.O. curated data and conducted formal analysis; N.A., R.K., K.H. and K.J. conducted the research and investigation process, specifically performing the experiments or collecting data/evidence; T.S. was entrusted with the leadership responsibility for the research activity planning and execution, including providing mentorship to the core team; M.S., T.K. and Y.O. created and/or presented the published work, specifically writing the initial draft; T.I. and T.K. performed critical review, commentary, or revision. All authors read and approved the final manuscript.Conflicts of interest statementThe Authors declares that there are no conflicts of interest.References