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Kosuke FUKAO1, 2), Hirofumi NISHIO2), Yuji TAKAZAWA1, 2)2)Department of Sports Medicine, Juntendo University, Chiba, Japan1)Graduate School of Health and Sports Science, Juntendo University Chiba, Japan4)Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan3)Innovative Medical Technology Research & Development Center, Juntendo University, Tokyo, JapanHidenori IZAWA1), Masashi NAGAO1, 3), Shojiro NOZU4), Yuki SHIOTA2), 228Corresponding author: Masashi NagaoInnovative Medical Technology Research & Development Center, Juntendo University Faculty of Medicine2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8121, JapanTEL: +81-3-3813-3111　E-mail: nagao@juntendo.ac.jp〔Received　Dec. 13, 2021〕〔Accepted　Jan. 20, 2022〕J-STAGE Advance published date: Jun. 2, 2022Copyright © 2022 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited. doi: 10.14789/jmj.JMJ21-0052-OAObjectives: This study aimed to investigate the effects of drinking oxygenated water on oxygen saturation during exercise under normobaric hypoxic conditions.Materials: A randomized placebo-controlled single-blinded trial was performed. Twenty-two healthy adults (16 men and 6 women), with a mean age (standard deviation) of 22.4 (2.73) years, participated in the study. The participants were randomly assigned to one of two groups: an OX group (drinking oxygenated mineral water) and a control group (drinking normal mineral water). Both groups performed walking exercises under normobaric hypoxic conditions. Blood oxygen saturation (SpO2), pulse rate (PR), and walking distance were measured during exercise.Results: SpO2 decreased and PR increased during exercise in both groups. The decrease in SpO2 was smaller and the increase in PR was greater in the OX group compared with those in the control group. No significant difference was found in walking distance between the two groups.Conclusions: Drinking oxygenated water before exercise may inhibit SpO2 reduction under normobaric hypoxic conditions.Key words: water, oxygen, hypoxia, randomized controlled trialJuntendo Medical Journal2022. 68(3), 228-234Original ArticlesEffects of Drinking Oxygenated Water on Blood Oxygen Saturation During Exercise Under Normobaric Hypoxic Conditions: A Randomized Placebo-controlled Single-blinded TrialIntroductionEnhancement of athletic ability is of interest not only for athletes, but for anyone engaged in playing sports. In recent years, to exploit the beneficial effects of oxygen on athletic performance, it has been proposed that drinking water containing high concentrations of dissolved oxygen may have the potential to improve athletic performance. A previous study demonstrated that high concentrations of dissolved oxygen in water (up to 40 times that of typical drinking water) improved athletic perfor-mance1). In addition, oxygenated water is marketed as a drink that can replenish water and oxygen, with claimed benefits including aiding recovery from fatigue after exercise and increasing concen-tration. However, scientific evidence regarding the effects of high-concentration oxygenated water remains controversial2-8). Because excessive enhance-ment of athletic performance can be detrimental to an athlete’s health and interfere with fair competi-tion, well-designed scientific experiments are needed.Under normal conditions, the partial pressure of oxygen is known to decrease with high-intensity training9, 10). In a study investigating exercise under normobaric hypoxic conditions, peripheral blood