68-2

53/110

54 newborns received probiotics for the total of 5 days, none of the newborns had any complications related to probiotic administration. There were only TcB level and no TSB level in this study, because invasive procedure such as blood draw is not permitted on a healthy infants. Also, analysis of intestinal microbiota was not done because there were no stool samples for taken from the subjects in this study.There was no significant difference in bilirubin level on day 1, 2, and 5 between probiotic and control groups. Also, we found no significant differ-ence in terms of suppressing the increase of bili-rubin level between day 5 – day 1 and day 5 – day 2. Bifidobacterium animalis subsp. lactis BB-12 is well tolerated in all infants and there was a signifi-cant (p = 0.031) weight gain in the probiotic groups. There were no side effects from the probi-otics founded in this study. However, the optimal time to administer probiotics, the strain, dose and duration require more studies. AcknowledgementsWe would like to thank the Sakuradai Maternity Clinic for their help in data collection.The authors received no financial support for the research.Author contributionsThe authors confirm contribution to the paper as follows:Study conception and design: IS, HS; data collec-tion: SI; analysis and interpretation of results: IS, HS; draft manuscript preparation: IS, HS, TS. All authors reviewed the results and approved the final version of the manuscript.Conflicts of interest statementThe Authors declare that there are no conflicts of interest. 1) Torkaman M, Mottaghizadeh F, Khosravi MH, Naja-fian B, Amirsalari S, Afsharpaiman S: The Effect of Probiotics on Reducing Hospitalization Duration in Infants With Hyperbilirubinemia. Iran J Pediatr, 2016; 27: e5096. 2) Suganthi V: Role of Saccharomyces boulardii in Reduc-tion of Neonatal Hyperbilirubinemia. J Clin Diagn Res, 2016; 10: SC12-SC15. 3) Makhoul G, Mardini J, Ojaimi MA, AbiFares G, Hanna P, Alameddine A, et al: Effect of Probiotic “L.Reuteri” Association on the Reduction of Serum Bilirubin in Neonatal Jaundice. Eur Sci J, 2018; 14: 384. 4) Chen K, Yuan T: The role of microbiota in neonatal hyperbilirubinemia. Am J Transl Res, 2020; 12: 7459-7474. 5) Chandrasekhar J, Varghese TP, Gopi A, Raj M, Sudevan R, Jayakumar H: Treatment Effect of Probiotic Bacillus Clausii on Neonatal Jaundice in Late Preterm and Term Newborn Babies: An Experimental Study. Pediatr Ther, 2017; 07: 189-196. 6) Hurkala J, Lauterbach R, Radziszewska R, Strus M, Heczko P: Effect of a Short-Time Probiotic Supple-mentation on the Abundance of the Main Constituents of the Gut Microbiota of Term Newborns Delivered by Cesarean Section-A Randomized, Prospective, Controlled Clinical Trial. Nutrients, 2020; 12: 3128. 7) Deshmukh J, Deshmukh M, Patole S: Probiotics for the management of neonatal hyperbilirubinemia: a system-atic review of randomized controlled trials. J Matern Fetal Neonatal Med, 2019; 32: 154-163. 8) Butel M-J, Waligora-Dupriet A-J, Wydau-Dematteis S: The developing gut microbiota and its consequences for health. J Dev Orig Health Dis, 2018; 9: 590-597. 9) Liu W, Liu H, Wang T, Tang X: Therapeutic effects of probiotics on neonatal jaundice. Pak J Med Sci, 2015; 31: 1172-1175. 10) El-Beshbishi SN, Shattuck KE, Mohammad AA, Petersen JR: Hyperbilirubinemia and Transcutaneous Bilirubi-nometry. Clin Chem, 2009; 55: 1280-1287. 11) Mutlu M, Aslan Y, Kader Ş, Aktürk Acar F: Preven-tive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization. Am J Perinatol, 2020; 37: 1173-1176. 12) Choi J, Lee S, Won J, Jin Y, Hong Y, Hur T-Y, et al: Pathophysiological and neurobehavioral characteris-tics of a propionic acid-mediated autism-like rat model. PloS One, 2018; 13: e0192925. 13) Zhang M, Ma W, Zhang J, He Y, Wang J: Analysis of gut microbiota profiles and microbe-disease associa-tions in children with autism spectrum disorders in China. Sci Rep, 2018; 8: 13981.14) Lu J, Claud EC: Connection between gut microbiome and brain development in preterm infants. Dev Psycho-biol, 2019; 61: 739-751. 15) Niemarkt HJ, De Meij TG, van Ganzewinkel C, de Boer NKH, Andriessen P, Hütten MC, et al: Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis. Neonatology, 2019; 115: 423-431. 16) Aarts E, Ederveen THA, Naaijen J, Zwiers MP, Boek-horst J, Timmerman HM, et al: Gut microbiome in ADHD and its relation to neural reward anticipation. 145LimitationConclusionsFundingReferences