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(n=271)4 ( 1.5%)51 (18.8%)131 (48.3%)69 (25.5%)16 ( 5.9 %)(n=259)6 ( 2.3%)21 ( 8.1%)88 (34.0%)117 (45.2%)27 (10.4 %)(p<0.01 in both cases). Furthermore, among all students, 43 (8.1%) had IRT scores lower than 400 as poor CBT results; 27 (10.4 %) without and 16 (5.9 %) with COVID-19, revealing a decrease in the latter (Table 1). 65432, 12. Science electives and performance during the third yearOn comparing performance between the sexes, females’ scores were higher. The rate of students with poor CBT scores was higher among males of the without COVID-19 group and among females of the with COVID-19 group.The students were further divided into physics and biology groups, irrespective of their science electives for university entrance examinations. The without COVID-19/physics group’s IRT score was 484.7±85.0, which was significantly lower than the 515.1±84.3 of the without COVID-19/biology group (p<0.01), and the number of members with poor CBT scores was as large as 21 (12.3%). In the with COVID-19 group, there were no differences related to science electives (Table 2).As for the students’ self-reported performance in their third year, those with poorer performance All values are shown as the mean ± SD (range). Statistical analysis was performed using t-test and chi-square test, in addition to JMP 9.0 (SAS Insti-tute Inc., Cary, NC, USA). The significance level was set at p<0.05 in all settings.Data regarding the students’ results were processed, adopting measures to prevent the iden-tification of individuals, and their written consent to the use of these data for research purposes was previously obtained. The present study was conducted with the approval of the ethics committee of Juntendo University (Approval number: 2018129).1. Comparison of performance between the without/with COVID-19 groupsThe overall mean IRT score was 515.5±85.4. The without and with COVID-19 groups’ scores were 495.7±85.9 and 534.4±80.8, respectively. Thus, the latter’s score was significantly higher (p<0.01) (Figure 1). On comparing the number of students at each grade based on their IRT scores, there were more students at Grades 4 and 5 and fewer students at Grade 3 in the with than without COVID-19 group IRT score≧ 700600 - 699500 - 599400 - 499＜400Figure 1　Overall mean IRT score and the Without/With COVID-19 groups’ IRT scoresGradeTotal(n=530)10 ( 1.9%)72 (13.6%)219 (41.3%)186 (35.1%)43 ( 8.1%)Table 1　Number of students at each gradeWithout COVID-19With COVID-19P-valueP＝0.48P＜0.01P＜0.01P＜0.01P＝0.06133Results