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syndrome and sinus node dysfunction” in the Journal of Arrhythmia as a compilation of our studies concerning BrS and SSS9). My first BrS patient encountered during my night shift at Juntendo University Hospital had a documented episode of VF 32 years earlier, and he has been doing well without syncope or an ICD operation since then. His recent ECG, recorded 30 years after his last VF episode, no longer showed Brugada-type ECG find-ings (Figure 5).I described a narrative concerning my clinical studies of BrS and SSS. These studies were inspired by a patient I encountered at Juntendo University Hospital. I believe that case report is very important for academic career because clinical studies may start with a clinical question in case presentation. Acknowledgements: I express my sincere gratitude to all the staff and members of the EP group at Juntendo University for their continuous support.Funding sources: None Disclosure: The author has no conflicts of interest to disclose. 1) Brugada P, Brugada J: Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol, 1992; 20: 1391-1396. 2) Sumiyoshi M, Nakata Y, Hisaoka T, et al: A case of idiopathic ventricular fibrillation with incomplete right bundle branch block and persistent ST segment eleva-tion. Jpn Heart J, 1993; 34: 661-666. 3) Chen Q, Kirsch GE, Zhang D, et al: Genetic basis and molecular mechanism for idiopathic ventricular fibril-lation. Nature, 1998; 392: 293-296. 4) Smith JP, Koopmann TT, Wilders R, et al: A mutation in the human cardiac sodium channel (E161K) contrib-utes to sick sinus syndrome, conduction disease, and Brugada syndrome in two families. J Moll Cell Cardiol, 2005; 38: 969-981. 5) Makiyama T, Akao M, Tsuji K, et al: High risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutation. J Am Coll Cardiol, 2005; 46: 2100-2106. 6) Makita N, Behr E, Shimizu W, et al: The E1784K muta-tion in SCN5A is associated with mixed clinical pheno-type of type 3 long QT syndrome. J Clin Invest, 2008; 118: 2219-2229. 7) Sumiyoshi M, Nakazato Y, Tokano T, et al: Sinus node dysfunction concomitant with Brugada syndrome. Circ J, 2008; 69: 946-950. 8) Hayashi H, Sumiyoshi M, Yasuda M, et al: Prevalence of the Brugada-type electrocardiogram and incidence of Brugada syndrome in patients with sick sinus syndrome. Circ J, 2010; 74: 271-277. 9) Hayashi H, Sumiyoshi M, Nakazato Y, Daida H: Brugada syndrome and sinus node dysfunction. J Arrhythmia, 2018; 34: 216-221.449EpilogueReferences