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the survival rate was significantly improved compared to the control group. In contrast, Gd+DST group had a significantly lower survival rate than the DST group.ConclusionsIt has been suggested that poor nutritional status of donors promotes preservation injury and contrib-436Figure 10　Kupffer cells in gadorinium-pretreated rat showed almost no carbon uptake.utes to a decrease in the viability of transplanted liver, and hepatic Kupffer cells are involved in the establishment of induction of specific immunolog-ical tolerance in donor specific blood transfusion.Thank you for your support for many years. We pray for everyone’s good health and the further development of Juntendo University.I have no conflicts of interest associated with this publication, and there has been no significant finan-cial support for this work that could have influ-enced its outcome. 1) Sato K, Nozaki H, Sakakibara N: Experimental studies on relationship donor starvation and graft viability after liver transplantation. Jpn J Gastroenterol Surg, 1993； 26： 2767−2774. 2) Sato K, Yabuki K, Haba T, Maekawa T: Role of Kupffer Cells in the Induction of Tolerance after Liver Trans-plantation. J Surg Res, 1996; 63: 433-438.AcknowledgementsReferences