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352person-years using the person-years method. For patients without increased uACR, this was 2.8 per 1,000 person-years. The odds ratio of patients without an increase in uACR was 0.29 (95%CI 0.07-0.96) (Table 5). The patients in Group L with a decrease in uACR did not require hospitalization. No significant difference was observed in comparison of other contributing factors (difference in sBP, with or without of oral drugs such as statin, LDL-C levels, HDL-C levels, and TG levels).DiscussionThis study includes 739 patients who are receiving outpatient treatment at a single hospital and relatively advanced in age (mean age of resi-dents: 66.9±12.3 years) as a target population. And this study is characterized by a capability of following up treatment progress in these patients over time. We examined the correlation among blood glucose (HbA1c), systolic blood pressure, Table 4　A factor analysis using logistic regression was performed on the decrease in eGFR for group LTable 5　A factor analysis was performed on the number of patients who were hospitalized due to cardiovascular or cerebrovascular eventsurinary protein (uACR) and renal function (eGFR) to identify the risk factors for development of nephropaty in patients with type 2 diabetes. In addition to type 2 diabetes, decreased renal function and increased proteinuria are known to induce cardiovascular and cerebrovascular events, and the result of this study were consistent with that finding.21-23) A positive correlation was observed between the increase in proteinuria and the risk for cardiovascular or cerebrovascular disease (CVD) events.9, 10, 15, 16) Our results suggest that the decrease in urinary protein excretion under strict blood glucose control may inhibit the occurrence of CVD events, and vice versa.ΔuACR/year and ΔeGFR/year in patients with an sBP of less than 130 mmHg were milder than in patients with an sBP of more than 130 mmHg. There was a strong relationship between the increase in proteinuria and the unsatisfactory control of blood pressure (sBP of more than 130 mmHg). Several biomarkers were evaluated in