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　　　2)Comparing Group M with other groups2) Comparing the annual change in uACR and eGFR 3)Comparing Group H with other groupsTable 1　Clinical characteristics of the diabetic subjectsGroup M(n=285)Population(n=739)male/femaleyears(mean) years(mean) %(mean)years(mean) mmHg(mean)(%)(%)(%)mg/dl(mean)mg/dl(mean)mg/dl(mean)mg/g・Cr(mean)ml/min/1.73㎡(mean)Group L(n=325)334/40566.9±12.38.74±6.07.24±1.03 2.24±0.99132.3±12.036.0%(267/739)51.8%(267/739)44.1%(326/739)109.6±26.656.４±15.6109.6±26.675.８±162.270.９±18.8202/12369.2±10.58.55±6.056.41±0.392.30±1.08130.6±10.429.7%(94/325)57.8%(188/325)46.8%(152/325)108.8±24.958.0±15.8108.8±24.951.6±310.766.8±37.2Group H(n=129)P-value59/7061.4±14.88.63±5.768.93±0.912.05±0.78135.5±13.449.6%(64/129)44.2%(57/129)42.7%(55/129)104.4±26.855.3±15.0104.4±26.8138.2±182.776.7±19.70.167<0.0010.182<0.0010.134<0.001<0.0010.01090.4310.0220.0040.021<0.001<0.001348Waha Transformer version 4.2.6.1 were used for the collection of patient data, data extraction and calculation. All statistical analyses were performed using the Easy R version 1.36. EZR is freely avail-able on the homepage of Jichi Medical University Saitama Medical Center. Statistical functions have been added to the R commander.Analyses of several biomarkers based on HbA1c levels1)Comparing Group L with other groupsMean eGFR levels in Group L were lower than those in the other two groups. Mean HDL-C levels and the number of patients with RASI in Group L were relatively higher than those in the other two groups.Mean LDL-C and TG levels in Group M during the measurement period were significantly higher than those in the other two groups. Mean age were significantly younger than those in the other two groups. Mean sBP were statisti-HbA1c levelGenderAgeDuration of diabetesHbA1c levelFollow up periodSystolic blood pressuresBP≧130RASI administrationStatin administrationLDL cholesterolHDL cholesterolTriglyceridesuACReGFRAge, Duration of diabetes, HbA1c, follow up period, systolic blood pressure, LDL-cholesterol values, HDL-cholesterol values, Triglycerides values, uACR and eGFR indicated by the mean ±SD. All subjects (n=739) classified into three groups according to the HbA1c level. sBP≧130, RASI administration, Statin administration, indicated by percentages. eGFR: estimated glomerular filtration rate. uACR: urine Albumin Creatinine Ratio. P<0.05 was consideration to be statistically significant (Kruskal-Wallis-test).cally significantly higher than those in the other two groups (p<0.001). Mean uACR levels were higher than those in the other two groups. There was no statistically significant difference in the number of patients administered statin, gender, duration of diabetes and measurement period among Groups L, M and H (Table 1).The annual change in proteinuria and renal function in all patients, and in Groups L, M and H1) Comparing the annual change in uACR and eGFR in all patientsThe annual change in proteinuria (ΔuACR/year) in the patients who had an sBP of less than 130 mmHg (12.1 mg/g・Cr/year) was significantly lower than those who had an sBP of more than 130 mmHg (27.8 mg/g・Cr/year) (p<0.001) (Figure 1). The annual change in eGFR (ΔeGFR/year) in the patients with RASI (-0.7mL/min/1.73m2) was not significantly less than that in the patients without RASI (-2.3 mL/min/1.73m2) (p<0.001) (Figure 2). in Groups L, M and HΔuACR/year in Group L patients who had an 126/15966.9±12.49.00±6.077.42±0.272.26±0.95132.8±11.439.0%(108/285)48.4%(138/285)41.8%(119/285)112.9±28.155.0±14.8113.0±28.175.1±194.272.9±19.7Results